Scientists Achieve First Complete Reversal of Type 2 Diabetes Thr...

A landmark clinical trial conducted at Massachusetts General Hospital and Stanford University Medical Centre demonstrated the first complete and durable reversal of Type 2 diabetes in adult patients through a single-dose gene therapy that reprogrammed pancreatic cells to restore insulin secretion. The trial enrolled 60 patients who had lived with Type 2 diabetes for an average of 14 years, all of whom discontinued all diabetes medication within six months of receiving the treatment. At the 18-month follow-up, 54 of 60 participants maintained normal blood glucose regulation with no pharmacological intervention. The therapy uses an adeno-associated virus vector to deliver a modified PDX1 transcription factor to pancreatic beta-cell precursors. India has an estimated 101 million people living with Type 2 diabetes — the highest burden of any country globally — and the Indian Council of Medical Research has initiated discussions to join Phase 3 expansion trials.